ARA-290 (Cibinetide) (Research Overview)
ARA-290, also called cibinetide, is an 11-residue linear peptide designed from the aqueous face of helix B of erythropoietin (EPO). It was developed to separate tissue-protective signaling studied for EPO from EPO's effects on red blood cell production.
Mechanism of Action
Studies describe ARA-290 as interacting with a receptor complex formed by the EPO receptor and the β-common receptor (CD131), sometimes called the innate repair receptor. Unlike EPO, it does not activate the classical EPO receptor homodimer used for erythropoiesis in published assays.
The peptide begins with pyroglutamate, which blocks the N-terminus, and has a listed molecular weight of about 1257 Da.
Research Areas
Preclinical work has used ARA-290 in rodent models of nerve injury, inflammation and metabolic stress, and it has been evaluated in early clinical studies as an investigational compound. It is not an approved drug.
For laboratory characterization, the pyroglutamyl N-terminus and the absence of cysteines are relevant: identity is confirmed by mass spectrometry, and N-terminal sequencing by Edman degradation is blocked.
Specification summary
ARA-290 (Cibinetide)
ARA-290 (Cibinetide) is coming soon to Sealed Peptides. Sizes and pricing are not yet listed; you can ask for one email when it is available. For laboratory research use only.
Related materials
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Laboratory background
Education for people working with this material in the laboratory: guides on handling and analysis, definitions of terms, and arithmetic tools. It describes no use of the material.
Guides
Glossary terms
References
- Dahan A, Brines M, Niesters M, Cerami A, van Velzen M. Targeting the innate repair receptor to treat neuropathy. Pain Rep. 2016;1(1):e566. PMID 29392190 · DOI
- Bohr S, Patel SJ, Vasko R, Shen K, Iracheta-Vellve A, Lee J, et al. Modulation of cellular stress response via the erythropoietin/CD131 heteroreceptor complex in mouse mesenchymal-derived cells. J Mol Med (Berl). 2015;93(2):199-210. PMID 25373867 · DOI
- Bitto A, Irrera N, Pizzino G, Pallio G, Mannino F, Vaccaro M, et al. Activation of the EPOR-β common receptor complex by cibinetide ameliorates impaired wound healing in mice with genetic diabetes. Biochim Biophys Acta Mol Basis Dis. 2018;1864(2):632-639. PMID 29223734 · DOI
- Swartjes M, van Velzen M, Niesters M, Aarts L, Brines M, Dunne A, et al. ARA 290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain coupled with suppression of the spinal microglia response. Mol Pain. 2014;10:13. PMID 24529189 · DOI
Cited literature is provided for scientific context only and does not describe or endorse any use of these products.
For laboratory research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.