Learn Learn: peptide laboratory science
Everything we publish about the science of working with research peptides, in one place: 18 guides, 26 compound overviews, a 80-term glossary, 5 calculators and 4 printable lab sheets. It is education about chemistry and laboratory practice; it describes no use of any material.
For laboratory research use only. Not for human or veterinary use. Cited literature is provided for scientific context only. Nothing here is medical advice.
Start with a question
Four short reading paths, in the order that tends to make sense.
The pieces
26 overviewsResearch libraryOne page per compound: structure, receptor or enzyme background and the cited literature. Searchable. 18 guidesLaboratory guidesHandling, solution arithmetic, storage, analysis and synthesis, with PubMed references. 80 termsGlossaryShort, neutral definitions with links to the guide that covers each term. 5 calculatorsLaboratory toolsConcentration, molarity, dilution, peptide mass and purity-content arithmetic. You enter every number. 4 PDFsPrintable lab sheetsSample log, storage log, concentration worksheet and vial inventory. Free, no sign-up. Guides by topic
Handling and solution arithmetic
Dissolving, diluting, freezing and storing: the arithmetic and the chemistry behind it.
Reconstitution Basics for Lyophilized Research PeptidesHow to prepare lyophilized research peptides — vehicle selection, technique, concentration math, and post-reconstitution handling.Reconstitution Math: How to Work Out Solution ConcentrationMaking a solution from a weighed or labelled amount of dry material comes down to a few lines of arithmetic. This guide sets out those lines, the assumptions hidden inside them, and the reasons a measured concentration can differ from the calculated one.Bacteriostatic Water vs Sterile Water: A Laboratory Diluent ComparisonBoth diluents are sterile water. One carries a preservative and one does not. This guide explains what that preservative is, what the word bacteriostatic actually promises, and why the choice of diluent is a variable worth recording.Freeze-Thaw Cycles and Aliquoting: Protecting Peptide Stock SolutionsFreezing a solution is not a pause button. Ice formation, concentrated solutes and container surfaces all act on the material while it is frozen and while it thaws. This guide explains the mechanisms and what published stability studies show about repeated cycles.Peptide Storage and Stability: Laboratory ReferenceLyophilized and reconstituted storage conditions, freeze–thaw discipline, bacteriostatic water in-use windows, and a practical checklist.Peptide Storage Stability and Degradation PathwaysPeptides change chemically and physically over time. Knowing the common routes helps you read an analytical result, keep useful records, and understand why storage conditions are written the way they are.Lyophilization: Why Research Peptides Are Freeze-DriedMost research peptides are supplied as a dry cake rather than a solution. This guide explains what lyophilization does, why it helps, and what a dry cake does and does not tell you.Peptide Solubility and Aggregation: Laboratory BasicsGetting a peptide into solution is a chemistry question with a predictable shape. This guide covers the factors that decide solubility, how aggregation shows up, and how to keep records that make a result repeatable. Analysis and quality documentation
How identity and purity are measured, what a report does and does not show, and why a label mass is not a peptide mass.
Synthesis
How synthetic peptides are made, and where the typical impurities come from.
Compound primers
Structure, chemistry and the cited literature for individual research compounds. Descriptive only.
What Is Semax? Structure, Chemistry and the Published ResearchSemax is a synthetic heptapeptide built from a fragment of adrenocorticotropic hormone and a Pro-Gly-Pro tail. This primer sets out what it is chemically, what the cited laboratory literature describes, and what that literature cannot tell you.What Is Selank? Structure, Chemistry and the Published ResearchSelank is a synthetic heptapeptide derived from the natural tetrapeptide tuftsin. This primer covers its structure and chemistry, the in-vitro and rodent literature behind it, and the limits of what that literature shows.What Is NAD+? The Coenzyme, Its Chemistry and the Published ResearchNAD+ is not a peptide. It is a small dinucleotide coenzyme found in every living cell. This primer explains what it is, the two roles the literature describes for it, how cells make and consume it, and what that means for the bench.What Is DSIP? The Delta Sleep-Inducing Peptide and Its Open QuestionsDSIP is a nine-residue peptide with a distinctive history. It was isolated in 1977, named for an effect seen in rabbits, and has stayed difficult to pin down since. This primer covers its chemistry and what the literature itself says is unresolved. Compound overviews
Each overview lists its PubMed references and links to the laboratory background that applies to it.
Common questions about this section
Do these pages tell me how to use a material?
No. The guides explain laboratory chemistry and arithmetic, such as how a concentration is calculated or why a peptide solution loses material when it is frozen. Sealed Peptides materials are supplied for in-vitro and laboratory research use only, and nothing on this site describes or recommends a use in people or animals.
Where do the citations come from?
Every reference in a guide or research overview is a PubMed record. The PMID links to the NCBI page, and the reference list is checked against NCBI before publication. Cited literature is provided for scientific context only.
Do the calculators suggest how much to use?
No. You enter every number, nothing is pre-filled, and the tools only convert units and show the formula used. Whether an amount is appropriate for an experiment is decided by your own protocol.
Is the research library the same as the guides?
No. A research overview describes one compound: its structure, receptor or enzyme background and the published literature. A guide covers a laboratory topic that applies to many materials, such as HPLC, storage or concentration arithmetic. The compound primers sit between the two.
Questions about a specific material, or a correction to something cited here? Write to support.
