Sermorelin (Research Overview)
Sermorelin is a synthetic peptide matching the first 29 residues of human growth hormone-releasing hormone (GHRH), with an amidated C-terminus. The 1–29 fragment is the shortest sequence reported to retain the full receptor activity of the 44-residue native hormone.
Mechanism of Action
Sermorelin binds the GHRH receptor (GHRH-R), a class B G protein-coupled receptor on pituitary somatotroph cells. Receptor activation raises intracellular cyclic AMP, the pathway through which GHRH signaling is studied.
Unmodified GHRH(1–29) is rapidly cleaved by dipeptidyl peptidase-4 and other proteases, giving it a short half-life in biological matrices. Later analogs, such as CJC-1295 and Tesamorelin, were designed with substitutions or added groups to extend that half-life, which makes Sermorelin a common reference compound in comparisons.
Research Areas
Research has used Sermorelin as a reference GHRH-receptor agonist in pituitary cell and animal models, and in studies of GHRH-receptor structure-activity relationships.
Sermorelin was previously marketed in the United States as a drug product that was later withdrawn by its manufacturer. Material sold by Sealed Peptides is for laboratory research use only.
Specification summary
Sermorelin
Sermorelin is coming soon to Sealed Peptides. Sizes and pricing are not yet listed; you can ask for one email when it is available. For laboratory research use only.
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From the research blog
Laboratory background
Education for people working with this material in the laboratory: guides on handling and analysis, definitions of terms, and arithmetic tools. It describes no use of the material.
Guides
References
- Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?. Clin Interv Aging. 2006;1(4):307-8. PMID 18046908 · DOI
- Cristea CD, Radu M, Toboc A, Stan C, David V. Cationic exchange SPE combined with triple quadrupole UHPLC-MS/MS for detection of GHRHs in urine samples. Anal Biochem. 2023;682:115336. PMID 37806509 · DOI
- Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006;91(3):799-805. PMID 16352683 · DOI
Cited literature is provided for scientific context only and does not describe or endorse any use of these products.
For laboratory research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.